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Effect of hormone replacement on exercise cardiopulmonary reserve and recovery performance in subclinical hypothyroidism.
Mainenti, M R M; Teixeira, P F S; Oliveira, F P; Vaisman, M.
Afiliação
  • Mainenti MR; Serviço de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Brasil. miriam.mainenti@hotmail.com
Braz J Med Biol Res ; 43(11): 1095-101, 2010 Nov.
Article em En | MEDLINE | ID: mdl-21088807
Subclinical hypothyroidism (SH) patients present cardiopulmonary, vascular and muscle dysfunction, but there is no consensus about the benefits of levothyroxine (L-T4) intervention on cardiopulmonary performance during exercise. The aim of the present study was to investigate the effects of L-T4 on cardiopulmonary exercise reserve and recovery in SH patients. Twenty-three SH women, 44 (40-50) years old, were submitted to two ergospirometry tests, with an interval of 6 months of normalization of thyroid-stimulating hormone (TSH) levels (L-T4 replacement group) or simple observation (TSH = 6.90 µIU/mL; L-T4 = 1.02 ng/dL). Patients with TSH >10 µIU/mL were excluded from the study to assure that they would receive treatment in this later stage of SH. Twenty 30- to 57-year-old women with no thyroid dysfunction (TSH = 1.38 µIU/mL; L-T4 = 1.18 ng/dL) were also evaluated. At baseline, lower values of gas exchange ratio reserve (0.24 vs 0.30; P < 0.05) were found for SH patients. The treated group presented greater variation than the untreated group for pulmonary ventilation reserve (20.45 to 21.60 L/min; median variation = 5.2 vs 25.09 to 22.45 L/min; median variation = -4.75, respectively) and for gas exchange ratio reserve (0.19 to 0.27; median variation = 0.06 vs 0.28 to 0.18; median variation = -0.08, respectively). There were no relevant differences in cardiopulmonary recovery for either group at baseline or after follow-up. In the sample studied, L-T4 replacement improved exercise cardiopulmonary reserve, but no modification was found in recovery performance after exercise during this period of analysis.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Consumo de Oxigênio / Tiroxina / Volume de Reserva Inspiratória / Ventilação Pulmonar / Terapia de Reposição Hormonal / Teste de Esforço / Hipotireoidismo Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Consumo de Oxigênio / Tiroxina / Volume de Reserva Inspiratória / Ventilação Pulmonar / Terapia de Reposição Hormonal / Teste de Esforço / Hipotireoidismo Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil