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Rabbit model of uncontrolled hemorrhagic shock and hypotensive resuscitation.
Rezende-Neto, J B; Rizoli, S B; Andrade, M V; Lisboa, T A; Cunha-Melo, J R.
Afiliação
  • Rezende-Neto JB; Departamento de Cirurgia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. jbrezende.ufmg@gmail.com
Braz J Med Biol Res ; 43(12): 1153-9, 2010 Dec.
Article em En | MEDLINE | ID: mdl-21085888
Clinically relevant animal models capable of simulating traumatic hemorrhagic shock are needed. We developed a hemorrhagic shock model with male New Zealand rabbits (2200-2800 g, 60-70 days old) that simulates the pre-hospital and acute care of a penetrating trauma victim in an urban scenario using current resuscitation strategies. A laparotomy was performed to reproduce tissue trauma and an aortic injury was created using a standardized single puncture to the left side of the infrarenal aorta to induce hemorrhagic shock similar to a penetrating mechanism. A 15-min interval was used to simulate the arrival of pre-hospital care. Fluid resuscitation was then applied using two regimens: normotensive resuscitation to achieve baseline mean arterial blood pressure (MAP, 10 animals) and hypotensive resuscitation at 60% of baseline MAP (10 animals). Another 10 animals were sham operated. The total time of the experiment was 85 min, reproducing scene, transport and emergency room times. Intra-abdominal blood loss was significantly greater in animals that underwent normotensive resuscitation compared to hypotensive resuscitation (17.1 ± 2.0 vs 8.0 ± 1.5 mL/kg). Antithrombin levels decreased significantly in normotensive resuscitated animals compared to baseline (102 ± 2.0 vs 59 ± 4.1%), sham (95 ± 2.8 vs 59 ± 4.1%), and hypotensive resuscitated animals (98 ± 7.8 vs 59 ± 4.1%). Evidence of re-bleeding was also noted in the normotensive resuscitation group. A hypotensive resuscitation regimen resulted in decreased blood loss in a clinically relevant small animal model capable of reproducing hemorrhagic shock caused by a penetrating mechanism.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ressuscitação / Choque Hemorrágico / Choque Traumático / Hidratação Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ressuscitação / Choque Hemorrágico / Choque Traumático / Hidratação Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil