Invasive pneumococcal disease in a third level pediatric hospital in Mexico City: epidemiology and mortality risk factors.
Salud Publica Mex
; 52(5): 391-7, 2010.
Article
em En
| MEDLINE
| ID: mdl-21031245
OBJECTIVE: To assess the epidemiologic characteristics of invasive pneumococcal diseases (IPD) among a population in a pediatric hospital in Mexico City and analyze mortality-related risk factors, serotype distribution and antibiotic susceptibility related to S.pneumoniae. MATERIAL AND METHODS: We performed a retrospective review of IPD cases at a third level pediatric hospital between 1997-2004. RESULTS: A total of 156 patients were included. The mortality rate was 27.5% and was associated with six pneumococcal serotypes: 14, 6B, 23F, 6A, 19F and 19A. There was no relationship between mortality and antimicrobial susceptibility pattern. A total of 28.2% of isolates were resistant to penicillin and 24.6% were resistant to cefotaxime. A statistically significant relationship was observed between mortality and previous underlying disease (CI 95%; 2.5-18.3; p< 0.05) using a multivariate logistic regression model. CONCLUSIONS: Our outcomes show that IPD mortality in our population is closely related to underlying disease and to six serotypes, five of which are included in the 7-valent pneumococcal conjugate vaccine.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Pneumocócicas
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Hospitais Urbanos
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Mortalidade Hospitalar
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Hospitais Pediátricos
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Salud Publica Mex
Ano de publicação:
2010
Tipo de documento:
Article
País de publicação:
México