Candidate genes and potential targets for therapeutics in Wilms' tumour.
Clin Transl Oncol
; 12(9): 597-605, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20851800
Wilms' tumour (WT) is the most common malignant renal tumour of childhood. During the past two decades or so, molecular studies carried out on biopsy specimens and tumour-derived cell lines have identified a multitude of chromosomal and epigenetic alterations in WT. In addition, a significant amount of evidence has been gathered to identify the genes and signalling pathways that play a defining role in its genesis, growth, survival and treatment responsiveness. As such, these molecules and mechanisms constitute potential targets for novel therapeutic strategies for refractory WT. In this report we aim to review some of the many candidate genes and intersecting pathways that underlie the complexities of WT biology.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tumor de Wilms
/
Genes Neoplásicos
Limite:
Humans
Idioma:
En
Revista:
Clin Transl Oncol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Canadá
País de publicação:
Itália