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Epidemiology of Streptococcus pneumoniae and Staphylococcus aureus colonization in healthy Venezuelan children.
Quintero, B; Araque, M; van der Gaast-de Jongh, C; Escalona, F; Correa, M; Morillo-Puente, S; Vielma, S; Hermans, P W M.
Afiliação
  • Quintero B; Department of Microbiology and Parasitology, Los Andes University, Mérida, Venezuela.
Eur J Clin Microbiol Infect Dis ; 30(1): 7-19, 2011 Jan.
Article em En | MEDLINE | ID: mdl-20803226
Streptococcus pneumoniae and Staphylococcus aureus cause significant morbidity and mortality worldwide. We investigated both the colonization and co-colonization characteristics for these pathogens among 250 healthy children from 2 to 5 years of age in Merida, Venezuela, in 2007. The prevalence of S. pneumoniae colonization, S. aureus colonization, and S. pneumoniae-S. aureus co-colonization was 28%, 56%, and 16%, respectively. Pneumococcal serotypes 6B (14%), 19F (12%), 23F (12%), 15 (9%), 6A (8%), 11 (8%), 23A (6%), and 34 (6%) were the most prevalent. Non-respiratory atopy was a risk factor for S. aureus colonization (p = 0.017). Vaccine serotypes were negatively associated with preceding respiratory infection (p = 0.02) and with S. aureus colonization (p = 0.03). We observed a high prevalence of pneumococcal resistance against trimethoprim-sulfamethoxazole (40%), erythromycin (38%), and penicillin (14%). Semi-quantitative measurement of pneumococcal colonization density showed that children with young siblings and low socioeconomic status were more densely colonized (p = 0.02 and p = 0.02, respectively). In contrast, trimethoprim-sulfamethoxazole- and multidrug-resistant-pneumococci colonized children sparsely (p = 0.03 and p = 0.01, respectively). Our data form an important basis to monitor the future impact of pneumococcal vaccination on bacterial colonization, as well as to recommend a rationalized and restrictive antimicrobial use in our community.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Pneumocócicas / Infecções Estafilocócicas / Staphylococcus aureus / Streptococcus pneumoniae / Portador Sadio Tipo de estudo: Etiology_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Limite: Child, preschool / Female / Humans / Male País/Região como assunto: America do sul / Venezuela Idioma: En Revista: Eur J Clin Microbiol Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Venezuela País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Pneumocócicas / Infecções Estafilocócicas / Staphylococcus aureus / Streptococcus pneumoniae / Portador Sadio Tipo de estudo: Etiology_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Limite: Child, preschool / Female / Humans / Male País/Região como assunto: America do sul / Venezuela Idioma: En Revista: Eur J Clin Microbiol Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Venezuela País de publicação: Alemanha