Influence of gestational age on pharmacokinetics of alfentanil in neonates.
Dev Pharmacol Ther
; 15(2): 82-5, 1990.
Article
em En
| MEDLINE
| ID: mdl-2078976
Alfentanil's small volume of distribution and short elimination half-life, coupled with its preservation of hemodynamic stability, make it a potentially useful drug for analgesia and anesthesia in neonates. The pharmacokinetics of alfentanil were studied in 5 infants born at 26-35 weeks' gestation and in 5 infants of greater than 36 weeks. All infants were studied in the first 3 days of life. After injection of 25 micrograms/kg alfentanil, there was no significant change in blood pressure or heart rate. No significant difference was observed in volume of distribution (0.84 +/- 0.48 l/kg vs. 0.82 +/- 0.30 l/kg), clearance (1.35 +/- 0.69 ml.kg-1.min-1 vs. 1.7 +/- 0.47 ml.kg-1.min-1), or effective half-life (455 +/- 111 min vs. 328 +/- 48 min) between the two groups. The pharmacokinetic values reported here for both preterm and full-term infants are significantly different from data reported for older children.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alfentanil
Limite:
Humans
/
Newborn
Idioma:
En
Revista:
Dev Pharmacol Ther
Ano de publicação:
1990
Tipo de documento:
Article
País de publicação:
Suíça