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A review of analytical techniques for determination of glimepiride: present and perspectives.
Bonfilio, Rudy; de Araújo, Magali Benjamim; Salgado, Hérida Regina Nunes.
Afiliação
  • Bonfilio R; Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas, UNESP-Univ Estadual Paulista, Araraquara-SP, Brazil.
Ther Drug Monit ; 32(5): 550-9, 2010 Oct.
Article em En | MEDLINE | ID: mdl-20736895
Glimepiride is an oral antidiabetic drug in the sulfonylurea class, which is widely used in treatment of Type 2 diabetes and it is currently available in more than 60 countries worldwide. As a result of the importance of this oral hypoglycemic agent in the treatment of noninsulin-dependent diabetes mellitus, this work aims to compile the published analytical methods reported so far in the literature for determination of glimepiride in biologic samples and pharmaceutical formulations. Techniques like high-performance liquid chromatography with ultraviolet, array-diode, mass spectroscopy, evaporative light scattering and charged aerosol detections, liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry, liquid chromatography-electrospray ionization-tandem mass spectrometry, semimicrobore high-performance liquid chromatography with column-switching, micellar electrokinetic chromatography, high-performance thin layer chromatography, polarography, and spectrophotometry have been used for analysis, from which it can be seen that high-performance liquid chromatography methods have been used most extensively.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Sulfonilureia / Hipoglicemiantes Limite: Humans Idioma: En Revista: Ther Drug Monit Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Sulfonilureia / Hipoglicemiantes Limite: Humans Idioma: En Revista: Ther Drug Monit Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos