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Association of complement factor H Y402H polymorphism and age-related macular degeneration in Brazilian patients.
Teixeira, Anderson G; Silva, Aldacilene S; Lin, Fabio L H; Velletri, Roberta; Bavia, Lorena; Belfort, Rubens; Isaac, Lourdes.
Afiliação
  • Teixeira AG; Department of Ophthalmology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Acta Ophthalmol ; 88(5): e165-9, 2010 Aug.
Article em En | MEDLINE | ID: mdl-20626361
PURPOSE: The aim of this study was investigate the association between complement Factor H polymorphism (Y402H) and age-related macular degeneration (AMD) in Brazilian patients. METHODS: Patients with AMD aged 50 or more and age-matched healthy controls were enrolled in the study. Genomic DNA was isolated from leucocytes of patients and controls; the Y402H polymorphism of complement Factor H gene (CFH) was determined by polymerase chain reaction directed sequencing. RESULTS: The frequency of 1277C allele of Factor H was 56.30% in patients with AMD compared with 36.51% in controls (p-value=0.001). The genotypic distribution differed significantly between the two groups (1277CC 36.98%, 1277CT 38.65% and 1277TT 24.37% for AMD group; 1277CC 13.16%, 1277CT 46.71% and 1277TT 40.13% for controls, p-value=0.001). The odds ratio for patients with AMD carrying only one 1277C allele was 1.36 and for those carrying two 1277C alleles was 4.63, when compared to the control group. CONCLUSIONS: These results suggest the Y402H polymorphism of CFH is a risk factor to the development of AMD in Brazilian patients. This is in accordance with findings from the majority of previous study population in Europe and North American.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Degeneração Macular Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Acta Ophthalmol Assunto da revista: OFTALMOLOGIA Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Degeneração Macular Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Acta Ophthalmol Assunto da revista: OFTALMOLOGIA Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido