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Baculovirus treatment fully protects mice against a lethal challenge of FMDV.
Molinari, Paula; García-Nuñez, Soledad; Gravisaco, M José; Carrillo, Elisa; Berinstein, Analía; Taboga, Oscar.
Afiliação
  • Molinari P; Instituto de Biotecnología, CNIA, INTA, Castelar, CC25 B1712WAA Buenos Aires, Argentina.
Antiviral Res ; 87(2): 276-9, 2010 Aug.
Article em En | MEDLINE | ID: mdl-20580746
Foot-and-mouth disease virus (FMDV) causes a highly contagious and economically devastating disease that affects cattle, swine, goat and sheep among others. FMDV is able to overcome the initial host innate immune response by inhibiting the induction of antiviral molecules at both the transcriptional and the translational levels. It has been demonstrated that FMDV A/Arg/2001 causes the death of adult C57Bl/6 mice within 72h. We evaluated the capacity of Autographa californica nuclear polyhedrosis virus (AcNPV), an insect virus with potent innate immunostimulating effects, to promote early protection against FMDV A/Arg/2001 challenge in C57Bl/6 mice. Groups of 8-9 weeks old female mice were injected intravenously with AcNPV and challenged with a lethal dose of FMDV at different times post-administration. Our results showed that pretreatment of mice with a single injection of AcNPV 3h or 3 days before FMDV challenge resulted in complete abrogation of mortality and complete or partial suppression of viremia, respectively. Furthermore, no signs of disease were observed. AcNPV could be a valuable tool to improve the design of a novel vaccine that protects as an adjuvant at early times post-vaccination.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia Biológica / Baculoviridae / Vírus da Febre Aftosa / Febre Aftosa Limite: Animals Idioma: En Revista: Antiviral Res Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Argentina País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia Biológica / Baculoviridae / Vírus da Febre Aftosa / Febre Aftosa Limite: Animals Idioma: En Revista: Antiviral Res Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Argentina País de publicação: Holanda