The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis.
Braz J Med Biol Res
; 43(7): 619-26, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-20549139
Micro-ribonucleic acids (microRNAs) are small molecules containing 20-23 nucleotides. Despite their small size, it is likely that almost every cellular process is regulated by them. Moreover, aberrant microRNA expression has been involved in the development of various diseases, including cancer. Although many data are available about the role of microRNAs in various lymphoproliferative disorders, their impact on the development of acute lymphoblastic leukemia of T-cell progenitors is largely unknown. In this review, we present recent information about how specific microRNAs are expressed and regulated during malignant T-lymphopoiesis and about their role during normal hematopoiesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Neoplásico
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Biomarcadores Tumorais
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Regulação Leucêmica da Expressão Gênica
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MicroRNAs
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Leucemia-Linfoma Linfoblástico de Células T Precursoras
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Hematopoese
Limite:
Humans
Idioma:
En
Revista:
Braz J Med Biol Res
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil