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High prevalence of thrombophilic traits in children with family history of thromboembolism.
Calhoon, Meghan J; Ross, Cassie N; Pounder, Elizabeth; Cassidy, Danielle; Manco-Johnson, Marilyn J; Goldenberg, Neil A.
Afiliação
  • Calhoon MJ; Section of Hematology, Oncology, and Bone Marrow Transplantation, Department of Pediatrics, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and The Children's Hospital, Aurora, CO 80045, USA.
J Pediatr ; 157(3): 485-9, 2010 Sep.
Article em En | MEDLINE | ID: mdl-20546786
OBJECTIVES: To determine a proximate family history of venous thromboembolism (VTE) in (1) the prevalence of thrombophilia; (2) the frequency of recommended changes in management resulting from thrombophilia evaluation; and (3) outcomes in longitudinal follow-up. STUDY DESIGN: Laboratory thrombophilia investigation was performed in 56 children with first- or second-degree family history of thromboembolism before age 55 years, but without personal history of thromboembolism, who were enrolled in a prospective inception cohort. VTE risk factors, family history, thrombophilia findings, and management recommendations were systematically collected, along with thromboembolism risk episodes/exposures, prophylactic anticoagulation, major bleeds, and thromboembolism events during follow-up. RESULTS: The frequencies of all thrombophilia traits were higher than the general population. Among 32 children who underwent complete laboratory evaluation, 34% had >or=2 traits. Thrombophilia testing led to recommendations for risk-based transient antithrombotic prophylaxis in 71% of subjects. No thromboembolism episodes developed during more than 900 patient-months of follow-up, although at-risk exposures were infrequent. CONCLUSION: Risk-stratified approaches to primary prevention of pediatric VTE should be further evaluated in cooperative prospective studies.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saúde da Família / Trombofilia / Tromboembolia Venosa Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: J Pediatr Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saúde da Família / Trombofilia / Tromboembolia Venosa Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: J Pediatr Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos