[Relation between selenium plasma levels and different prostatic pathologies]. / Relación entre los niveles plasmáticos de selenio y las diferentes enfermedades prostáticas.
Actas Urol Esp
; 34(7): 625-9, 2010 Jul.
Article
em Es
| MEDLINE
| ID: mdl-20540880
UNLABELLED: Several studies have demonstrated an inverse relation between serum selenium levels (Se) and advanced prostate cancer (PCa). OBJECTIVE: To determine and compare selenium plasma levels in patients with different prostatic pathologies. MATERIAL AND METHODS: It is a transversal, descriptive and comparative study. A sample of 64 men between 50 and 80 years old were selected for the study between 2007 and 2009. All volunteers underwent a digital rectal examination, prostate specific antigen level, ultrasound and transrectal prostate biopsy (12-14 chips). Prostate cancer was subclassified according to Gleason Score. Selenium was determined indirectly by serum Glutathione peroxidase (Kit Ransel, Randox SRL, Crumlin, UK). Statistical analysis was performed using ANOVA I (p<0.05). RESULTS: Glutathione Peroxidase level was 33.75+/-2.36 mg/ml in control patients. A decrease of 31.6% was observed in patients with BPH (23.08+/-1.57 mg/ml) and of (63.6%) in subjects with prostate cancer (12.28+/-1.03 mg/ml) (p<0,0001). There was no correlation with the Gleason Score. CONCLUSION: Serum Seleniun is lower in patients with prostatic pathologies being even more important in cancer patients regardless the Gleason Score.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Prostáticas
/
Neoplasias da Próstata
/
Selênio
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
Es
Revista:
Actas Urol Esp
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Espanha