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Controlled trial of active tuberculosis case finding in a Brazilian favela.
Miller, A C; Golub, J E; Cavalcante, S C; Durovni, B; Moulton, L H; Fonseca, Z; Arduini, D; Chaisson, R E; Soares, E C C.
Afiliação
  • Miller AC; Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland, USA. millera@hsph.harvard.edu
Int J Tuberc Lung Dis ; 14(6): 720-6, 2010 Jun.
Article em En | MEDLINE | ID: mdl-20487610
SETTING: A large, impoverished squatters' settlement (favela), Rio de Janeiro, Brazil. OBJECTIVE: To assess the community impact of active case finding for tuberculosis (TB) compared to an enhanced case-finding strategy. DESIGN: A pair-matched, cluster-randomized trial comparing household symptom screening and spot sputum collection (Arm 1) vs. distribution of an educational pamphlet (Arm 2) was performed in a large Brazilian favela. We compared TB case-notification rates, time from symptom onset to treatment start and treatment completion proportions between arms. Fourteen neighborhoods (estimated population 58,587) were pair-matched by prior TB case rates and randomly allocated to one of two interventions. TB was diagnosed using acid-fast bacilli smears. New TB cases were interviewed and clinic records were reviewed. RESULTS: A total of 193 TB cases were identified in the 14 study neighborhoods (incidence proportion 329 per 100,000 population). The case identification rate in Arm 1 was 934/100,000 person-years (py) vs. 604/100,000 py in Arm 2 (RR 1.55, 95%CI 1.10-1.99). No significant differences were found in time from cough onset to treatment start or proportion completing treatment. CONCLUSIONS: A door-to-door case-finding campaign was more effective (while ongoing) at detecting prevalent cases and influencing people to come for care than leafleting, but no differences were seen in time to treatment start or treatment completion.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escarro / Tuberculose Pulmonar / População Urbana / Programas de Rastreamento / Mycobacterium tuberculosis Tipo de estudo: Diagnostic_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Aspecto: Determinantes_sociais_saude Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int J Tuberc Lung Dis Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escarro / Tuberculose Pulmonar / População Urbana / Programas de Rastreamento / Mycobacterium tuberculosis Tipo de estudo: Diagnostic_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Aspecto: Determinantes_sociais_saude Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int J Tuberc Lung Dis Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: França