Yeast as a model to study mitochondrial mechanisms in ageing.
Mech Ageing Dev
; 131(7-8): 494-502, 2010.
Article
em En
| MEDLINE
| ID: mdl-20450928
Despite the fact that ageing necessarily displays unique aspects in a single-cell organism, yeast, in particular Saccharomyces cerevisiae, are useful as model organisms to study ageing. Here we review mitochondrial characteristics involved in yeast longevity, including biogenesis, autophagy, respiration and oxidative phosphorylation, nutrient sensing, mitochondria-nuclear signaling, redox state and mitochondrial DNA integrity. Altogether, the yeast model unearths a rich and complex network involving many mitochondrial functions in ageing, and uncovers physiological and genetic mechanisms capable of extending lifespan in this model which may be shared with more complex organisms.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Envelhecimento
/
Mitocôndrias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Mech Ageing Dev
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Irlanda