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Aqueous garlic extracts prevent oxidative stress and vascular remodeling in an experimental model of metabolic syndrome.
Vazquez-Prieto, Marcela Alejandra; González, Roxana Elizabeth; Renna, Nicolás Federico; Galmarini, Claudio Rómulo; Miatello, Roberto Miguel.
Afiliação
  • Vazquez-Prieto MA; Area de Fisiología Patologica, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.
J Agric Food Chem ; 58(11): 6630-5, 2010 Jun 09.
Article em En | MEDLINE | ID: mdl-20450156
The organosulfur profile and the effect on oxidative stress and vascular remodeling in fructose-fed rats (FFR) were evaluated in Fuego INTA and Morado INTA garlic cultivars. Wistar rats were fed either normal rat chow (control) or the same diet plus 10% fructose in drinking water. During the last 6 weeks of a 12 week period of the corresponding diet, a subgroup of control and FFR received an aqueous extract of Fuego INTA and Morado INTA. Fuego INTA showed higher levels of total thiosulfinates, allicin, and pungency than Morado INTA. FFR showed an increase of systolic blood pressure, aortic NAD(P)H oxidase activity, plasma thiobarbituric acid reactive substances, and vascular remodeling that was significantly reduced after both garlic administrations. The beneficial effect was slightly higher when Fuego INTA was administered. Both aqueous garlic extracts prevent oxidative stress and vascular remodeling in rats with metabolic syndrome, suggesting the existence of slight differences among cultivars.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artéria Renal / Extratos Vegetais / Estresse Oxidativo / Síndrome Metabólica / Alho / Rim Limite: Animals / Humans / Male Idioma: En Revista: J Agric Food Chem Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artéria Renal / Extratos Vegetais / Estresse Oxidativo / Síndrome Metabólica / Alho / Rim Limite: Animals / Humans / Male Idioma: En Revista: J Agric Food Chem Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos