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Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.
Iwasaki, Motoki; Hamada, Gerson Shigeaki; Nishimoto, Ines Nobuko; Netto, Mario Mourão; Motola, Juvenal; Laginha, Fábio Martins; Kasuga, Yoshio; Yokoyama, Shiro; Onuma, Hiroshi; Nishimura, Hideki; Kusama, Ritsu; Kobayashi, Minatsu; Ishihara, Junko; Yamamoto, Seiichiro; Hanaoka, Tomoyuki; Tsugane, Shoichiro.
Afiliação
  • Iwasaki M; Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan. moiwasak@ncc.go.jp
Nutr Cancer ; 62(4): 466-75, 2010.
Article em En | MEDLINE | ID: mdl-20432167
We tested the hypothesis that polymorphisms in cytochrome P450c17alpha (CYP17), aromatase (CYP19), 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1) and sex hormone-binding globulin (SHBG) genes may modify the association between isoflavone intake and breast cancer risk. We conducted hospital-based, case-control studies in Nagano, Japan and Sao Paulo, Brazil. A total of 846 pairs (388 Japanese, 79 Japanese Brazilians, and 379 non-Japanese Brazilians) completed validated food frequency questionnaires. Four single nucleotide polymorphisms (SNPs) in CYP17 (rs743572), CYP19 (rs10046), 17beta-HSD1 (rs605059), and SHBG (rs6259) genes were genotyped. We found no association between the 4 SNPs and breast cancer risk. In combination analyses of isoflavone intake and SNPs, an inverse association between intake and risk was limited to women with at least one A allele of the rs605059 polymorphism for all 3 populations, albeit without statistical significance. For the rs6259 polymorphism, the inverse association was limited to postmenopausal Japanese with the GG genotype (odds ratio [OR] for highest vs. lowest tertile = 0.50, 95% confidence interval [CI] = 0.29-0.87; P for trend < 0.01), and to non-Japanese Brazilians with at least one A allele (OR for consumers vs. nonconsumer = 0.21, 95% CI = 0.06-0.77). We found no remarkable difference for the rs743572 and rs10046 polymorphisms. Our findings suggest that polymorphisms in the 17beta-HSD1 and SHBG genes may modify the association between isoflavone intake and breast cancer risk.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esteroide Hidroxilases / Neoplasias da Mama / Globulina de Ligação a Hormônio Sexual / Polimorfismo de Nucleotídeo Único / Estradiol Desidrogenases / Isoflavonas Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged País/Região como assunto: America do sul / Asia / Brasil Idioma: En Revista: Nutr Cancer Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Japão País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esteroide Hidroxilases / Neoplasias da Mama / Globulina de Ligação a Hormônio Sexual / Polimorfismo de Nucleotídeo Único / Estradiol Desidrogenases / Isoflavonas Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged País/Região como assunto: America do sul / Asia / Brasil Idioma: En Revista: Nutr Cancer Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Japão País de publicação: Estados Unidos