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Family history of hypertension as an important risk factor for the development of severe preeclampsia.
Bezerra, Patricia C F M; Leão, Marcos D; Queiroz, José W; Melo, Edailna M D; Pereira, Flávio V M; Nóbrega, Maria Hebe; Jeronimo, Ana K; Ferreira, Leonardo C; Jerônimo, Selma M B; de Araújo, Ana Cristina P F.
Afiliação
  • Bezerra PC; Health Graduate Program, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
Acta Obstet Gynecol Scand ; 89(5): 612-7, 2010 May.
Article em En | MEDLINE | ID: mdl-20423274
OBJECTIVE: To determine the risk of preeclampsia in a population with respect to maternal and sister histories of chronic hypertension, preeclampsia and eclampsia. DESIGN: A case-control study of severe preeclampsia. SETTING: Maternity hospital in Natal, Brazil. PARTICIPANTS: A total of 412 subjects were enrolled, 148 cases and 264 controls. MAIN OUTCOME MEASURES: Personal and familial histories of hypertensive disorders. Odds ratio estimates of preeclampsia with respect to family history of hypertensive diseases. RESULTS: Women with a history of hypertensive disorders were more frequent in the case group (p = 0.001). Women whose mothers had a history of hypertension (p = 0.003), preeclampsia (p = 0.007) or eclampsia (p = 0.038) were at increased risk of severe preeclampsia. The risk of preeclampsia was greater when the woman had a sister with a history of hypertension (OR 2.60, 95% CI 1.60-4.21, p < 0.001), preeclampsia (OR 2.33, 95% CI 1.58-3.45, p < 0.001), or eclampsia (OR 2.57, 95% CI 1.28-5.16, p = 0.008). The risk of preeclampsia was also higher for women who had both a mother and sister with a history of hypertension (OR 3.65, 95% CI 1.65-8.09, p = 0.001). CONCLUSIONS: A family history of hypertensive disorders increased the risk of eclampsia and hemolysis elevated liver enzymes and low platelet (HELLP) syndrome in a Brazilian population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pré-Eclâmpsia / Resultado da Gravidez / Predisposição Genética para Doença / Hipertensão Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy País/Região como assunto: America do sul / Brasil Idioma: En Revista: Acta Obstet Gynecol Scand Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pré-Eclâmpsia / Resultado da Gravidez / Predisposição Genética para Doença / Hipertensão Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy País/Região como assunto: America do sul / Brasil Idioma: En Revista: Acta Obstet Gynecol Scand Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos