Antidepressant-like profile and MAO-A inhibitory activity of 4-propyl-2H-benzo[h]-chromen-2-one.
Life Sci
; 86(21-22): 819-24, 2010 May 22.
Article
em En
| MEDLINE
| ID: mdl-20394758
AIMS: To evaluate the central nervous pharmacological profile of 4-propyl-2H-benzo[h]-chromen-2-one (FCS-304) in ICR mice and its monoamine oxidase inhibitor activity. MAIN METHODS: FCS-304 was evaluated in screening test of central nervous system in ICR mice and against MAO activity. KEY FINDINGS: FCS-304 (25-200mg/Kg, p.o.) significantly reduced immobility time during the forced swimming test (FST) and tail suspension test (TST), but did not show effects in the rota-rod tests, maximal electroshock seizures (MES), pentylenetetrazole seizures, light-dark box, barbiturate sleeping time and cold plate tests. Furthermore, FCS-304 inhibited monoamine oxidase A (MAO-A) with IC50: 2.28+/-0.15microM, but not MAO-B. SIGNIFICANCE: These results suggest that FCS-304 could elicit antidepressant effects related to MAO-A inhibitory activity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromonas
/
Inibidores da Monoaminoxidase
/
Antidepressivos
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Colômbia
País de publicação:
Holanda