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Risk factors for acute kidney injury in visceral leishmaniasis (Kala-Azar).
Oliveira, Michelle J C; Silva Júnior, Geraldo B; Abreu, Krasnalhia Lívia S; Rocha, Natália A; Garcia, Ana Valeska V; Franco, Luiz F L G; Mota, Rosa M S; Libório, Alexandre B; Daher, Elizabeth F.
Afiliação
  • Oliveira MJ; Department of Internal Medicine, School of Medicine, Federal University of Ceará, Ceará, Brazil.
Am J Trop Med Hyg ; 82(3): 449-53, 2010 Mar.
Article em En | MEDLINE | ID: mdl-20207871
The aim of this study was to investigate the factors associated with acute kidney injury (AKI) in patients with visceral leishmaniasis (VL). The study patients had a diagnosis of VL and were admitted to a tertiary hospital. A multivariate analysis was performed to analyze the risk factors for AKI. A total of 224 patients were included. The mean age was 36 +/- 15 years. AKI was observed in 33.9% of cases. Risk factors associated with AKI were male gender (odds ratio [OR] = 2.2; P = 0.03), advanced age (OR = 1.05; P < 0.001), and jaundice (OR = 2.9; P = 0.002). There was an association between amphotericin B use and AKI (OR = 18.4; P < 0.0001), whereas glucantime use was associated with lower incidence of AKI compared with amphotericin B use (OR = 0.05; P < 0.0001). Mortality was 13.3%, and it was higher in AKI patients (30.2%). Therefore, factors associated with AKI were male gender, advanced age, and jaundice. Amphotericin B was an important cause of AKI in VL.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nefropatias / Leishmaniose Visceral Tipo de estudo: Etiology_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Trop Med Hyg Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nefropatias / Leishmaniose Visceral Tipo de estudo: Etiology_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Trop Med Hyg Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos