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An association study between the Val66Met polymorphism of the BDNF gene and postpartum depression.
Figueira, Patrícia; Malloy-Diniz, Leandro; Campos, Simone B; Miranda, Débora M; Romano-Silva, Marco Aurélio; De Marco, Luiz; Neves, Fernando S; Correa, Humberto.
Afiliação
  • Figueira P; Laboratory of Neuroscience, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Arch Womens Ment Health ; 13(3): 285-9, 2010 Jun.
Article em En | MEDLINE | ID: mdl-20169377
Postpartum depression disorder (PPD) is a severe illness affecting around 15% of deliveries. Several evidences suggest that PPD is, at least, partially genetic determined. The gene encoding BDNF is a strong candidate for pathogenesis of PPD since that it has been observed decrease of serum BDNF in patients suffering from PPD. The gene encoding BDNF has a polymorphism (Val66Met) that alters the regulated protein secretion; the methionine variant being associated with insufficient secretion compared with the Valine variant. We hypothesized that BDNF gene Val66Met polymorphism could be associated with PPD. We assessed 227 subjects randomly selected who had delivery at a maternity hospital using EPDS. Differences in genotype frequency were calculated by chi (2) test. Logistic Regression Analyses was performed to verify the existence of interaction between biological, psychiatric and environmental variables and PPD. Difference between groups was tested with Student's t test. Tests were two-tailed and results significant when p < or = 0.05. No difference in BDNF genotype distribution was observed between the depressed and non-depressed women. Educational level, stress during pregnancy, bipolar disorder and anxiety was strongly associated with PPD. We were not able to show an association between BDNF polymorphisms and PPD. Further studies are necessary to both of confirm our results and improve validity of PPD diagnosis.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Depressão Pós-Parto / Fator Neurotrófico Derivado do Encéfalo Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Arch Womens Ment Health Assunto da revista: PSICOLOGIA / SAUDE DA MULHER Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Áustria

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Depressão Pós-Parto / Fator Neurotrófico Derivado do Encéfalo Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Arch Womens Ment Health Assunto da revista: PSICOLOGIA / SAUDE DA MULHER Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Áustria