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Immunoexpression of Cbfa-1/Runx2 and VEGF in sinus lift procedures using bone substitutes in rabbits.
De Souza Nunes, Leandro Soeiro; De Oliveira, Renato Victor; Holgado, Leandro Andrade; Nary Filho, Hugo; Ribeiro, Daniel Araki; Matsumoto, Mariza Akemi.
Afiliação
  • De Souza Nunes LS; Department of Health Sciences, Discipline of Oral and Maxillofacial Surgery, School of Dentistry, Sagrado Coração University, USC, Bauru, Sao Paulo, SP, Brazil.
Clin Oral Implants Res ; 21(6): 584-90, 2010 Jun.
Article em En | MEDLINE | ID: mdl-20105194
OBJECTIVES: To analyze and compare the expression of core binding factor-1 (Cbfa-1)/Runx2 and vascular endothelium growth factor (VEGF) in sinus lift procedures using bovine hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP). MATERIAL AND METHODS: Twenty-four male rabbits that had undergone bilateral sinus lift procedures were divided into three groups, according to the sinus filling material: Group 1: autogenous bone graft; Group 2: bovine HA; and Group 3: beta-TCP. All groups were sacrificed after 7, 14, 30 and 60 days, for microscopic, histomorphometry and immunohistochemistry analysis. RESULTS: Microscopic analysis showed a similar bone repair pattern between the tested groups. New bone formation, soft and medular tissue, remaining material or particulate bone graft area were obtained by histomorphometric analysis. After 14 days, statistically significant differences in new bone formation were found between Group 1 (27.76+/-7.8) and Groups 2 (14.22+/-3.2) and 3 (11.1+/-7.7). After 30 days, statistically significant differences (P<0.05) were detected in bone formation between Groups 1 (31.39+/-36.5) and 2 (14.13+/-3.2). The last period showed improved bone formation in Group 2. Also, Group 2 showed higher Cbfa-1/Runx2 immunoexpression when compared with Group 3. No remarkable differences were observed in VEGF immunoexpression among groups. CONCLUSION: Taken together, both biomaterials allowed bone tissue growth in a conductive pattern and did not interfere with bone remodeling in the late period, with a slight improvement in bone tissue formation when using HA, confirmed by marked expression of Cbfa-1 at initial periods.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Substitutos Ósseos / Fator A de Crescimento do Endotélio Vascular / Subunidade alfa 1 de Fator de Ligação ao Core / Seio Maxilar Limite: Animals Idioma: En Revista: Clin Oral Implants Res Assunto da revista: ODONTOLOGIA Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Dinamarca
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Substitutos Ósseos / Fator A de Crescimento do Endotélio Vascular / Subunidade alfa 1 de Fator de Ligação ao Core / Seio Maxilar Limite: Animals Idioma: En Revista: Clin Oral Implants Res Assunto da revista: ODONTOLOGIA Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Dinamarca