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Alcohol consumption and sudden unexpected death in epilepsy: experimental approach.
Scorzai, Carla A; Cysneiros, Roberta M; Arida, Ricardo M; Terra, Vera C; Machado, Hélio R; de Almeida, Antonio-Carlos G; Cavalheiro, Esper A; Scorza, Fulvio A.
Afiliação
  • Scorzai CA; Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Arq Neuropsiquiatr ; 67(4): 1003-6, 2009 Dec.
Article em En | MEDLINE | ID: mdl-20069209
Using the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence. Rats were divided randomly into two groups: (A) rats with epilepsy and (B) rats with epilepsy that received a daily dose of ethanol solution (350 mg kg(-1), i.p.) for 30 days. The basal frequency of seizures observed in the A and B groups during the first 30 days were 3.4+/-1.5 and 3.2+/-1.9 seizures per week per animal, respectively. In B group, it was observed a significant seizure increase (11.6+/-5.3) during the first 2 weeks of alcohol administration and quite interesting, one rat died suddenly after a generalized tonic-clonic seizure during this period. We concluded in our experimental study that exist a possible association between alcohol abuse and SUDEP occurrence.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Consumo de Bebidas Alcoólicas / Morte Súbita / Epilepsia Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Arq Neuropsiquiatr Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Consumo de Bebidas Alcoólicas / Morte Súbita / Epilepsia Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Arq Neuropsiquiatr Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha