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Exercise training prevents hyperinsulinemia, muscular glycogen loss and muscle atrophy induced by dexamethasone treatment.
Barel, Matheus; Perez, Otávio André Brogin; Giozzet, Vanessa Aparecida; Rafacho, Alex; Bosqueiro, José Roberto; do Amaral, Sandra Lia.
Afiliação
  • Barel M; Department of Physical Education, School of Science, São Paulo State University, UNESP, Bauru, SP, Brazil.
Eur J Appl Physiol ; 108(5): 999-1007, 2010 Mar.
Article em En | MEDLINE | ID: mdl-19967395
This study investigated whether exercise training could prevent the negative side effects of dexamethasone. Rats underwent a training period and were either submitted to a running protocol (60% physical capacity, 5 days/week for 8 weeks) or kept sedentary. After this training period, the animals underwent dexamethasone treatment (1 mg/kg per day, i.p., 10 days). Glycemia, insulinemia, muscular weight and muscular glycogen were measured from blood and skeletal muscle. Vascular endothelial growth factor (VEGF) protein was analyzed in skeletal muscles. Dexamethasone treatment evoked body weight loss (-24%), followed by muscular atrophy in the tibialis anterior (-25%) and the extensor digitorum longus (EDL, -15%). Dexamethasone also increased serum insulin levels by 5.7-fold and glucose levels by 2.5-fold compared to control. The exercise protocol prevented atrophy of the EDL and insulin resistance. Also, dexamethasone-treated rats showed decreased muscular glycogen (-41%), which was further attenuated by the exercise protocol. The VEGF protein expression decreased in the skeletal muscles of dexamethasone-treated rats and was unaltered by the exercise protocol. These data suggest that exercise attenuates hyperglycemia and may also prevent insulin resistance, muscular glycogen loss and muscular atrophy, thus suggesting that exercise may have some benefits during glucocorticoid treatment.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Dexametasona / Atrofia Muscular / Músculo Esquelético / Glicogênio / Hiperinsulinismo Tipo de estudo: Evaluation_studies / Guideline Limite: Animals Idioma: En Revista: Eur J Appl Physiol Assunto da revista: FISIOLOGIA Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Dexametasona / Atrofia Muscular / Músculo Esquelético / Glicogênio / Hiperinsulinismo Tipo de estudo: Evaluation_studies / Guideline Limite: Animals Idioma: En Revista: Eur J Appl Physiol Assunto da revista: FISIOLOGIA Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha