Relaxant effect of benzodiazepines on uterine rings isolated from estrogen-treated rats.
Eur J Pharmacol
; 185(2-3): 231-4, 1990 Aug 28.
Article
em En
| MEDLINE
| ID: mdl-1979275
K(+)-contracted rat uterine rings were relaxed in a concentration-dependent manner by the benzodiazepines Ro 5-4864, diazepam and clonazepam, as well as by the putative peripheral benzodiazepine antagonist PK 11195. The relaxation induced by diazepam was not counteracted by the central antagonist Ro 15-1788 (10 microM), and the relaxant effects of Ro 5-4864 and of diazepam were not prevented by either the GABAA antagonist bicuculline (10 microM) or the beta-adrenoceptor antagonist propranolol (1 microM). The mechanism underlying the relaxant effects of benzodiazepines on K(+)-contracted uterine rings is still under study.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ansiolíticos
/
Contração Uterina
/
Estrogênios
/
Músculo Liso
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Holanda