Sleep variables are unaltered by zolantidine in rats: are histamine H2-receptors not involved in sleep regulation?
Brain Res Bull
; 25(2): 229-31, 1990 Aug.
Article
em En
| MEDLINE
| ID: mdl-1977498
The effects of the H1-receptor antagonist diphenhydramine and the brain-penetrating H2-receptor antagonist zolantidine were studied in rats implanted for chronic sleep recordings. Diphenhydramine (1.0-4.0 mg/kg) significantly increased slow wave sleep and decreased wakefulness. Zolantidine (0.25-8.0 mg/kg) had no significant effects on any of the sleep parameters examined. One possibility is that zolantidine did not enter the brain in sufficient concentration to produce significant changes on sleep and wakefulness. Another possibility is that blockade of H2-receptor involved parts of the brain other than those implicated in the sleep-wake cycle. The feasibility remains that H2-receptors are not involved in sleep regulation. The absence of selective, brain-penetrating H2-receptor agonists precludes a more detailed analysis of the role of this subtype of receptor in the control of sleep and wakefulness.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Sono
/
Tiazóis
/
Receptores Histamínicos H2
/
Antagonistas dos Receptores H2 da Histamina
Limite:
Animals
Idioma:
En
Revista:
Brain Res Bull
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Uruguai
País de publicação:
Estados Unidos