[Gene-nutrient interaction and its association with obesity and diabetes mellitus]. / Interação entre gene e nutriente e sua associação à obesidade e ao diabetes melito.
Arq Bras Endocrinol Metabol
; 53(5): 497-508, 2009 Jul.
Article
em Pt
| MEDLINE
| ID: mdl-19768241
Nutritional genomics evaluates the effects of genetic variation in the interaction between diet and chronic diseases. The aim of this manuscript was to review the most important genetic polymorphisms associated with obesity, diabetes mellitus, and dietary factors. The main interactions among genetic polymorphisms and diet were: for obesity: interleukin-6 (IL-6) with daily intake; peroxisome proliferator-activated receptor gamma 2 (PPAR-gama2) and fat mass and obesity associated (FTO) with fat intake; beta-adrenergic receptor 2 (ADRB2) and melanocortin receptor 4 (MCR4) with carbohydrate intake; or reduction in body weight: uncoupling proteins (UCPs) with restriction of energy; for leptinemia: leptin receptor (LEPR) with restriction of energy; for diabetes mellitus: PPAR-gama2 with fat intake; for hypertriglyceridemia: fatty acid-binding protein 2 (FABP2) with fat intake. The data demonstrated suggest that nutritional genomics is important for the development of obesity and diabetes mellitus.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Diabetes Mellitus
/
Nutrigenômica
/
Obesidade
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
Pt
Revista:
Arq Bras Endocrinol Metabol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil