Argemone mexicana decoction versus artesunate-amodiaquine for the management of malaria in Mali: policy and public-health implications.
Trans R Soc Trop Med Hyg
; 104(1): 33-41, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19733875
A classic way of delaying drug resistance is to use an alternative when possible. We tested the malaria treatment Argemone mexicana decoction (AM), a validated self-prepared traditional medicine made with one widely available plant and safe across wide dose variations. In an attempt to reflect the real situation in the home-based management of malaria in a remote Malian village, 301 patients with presumed uncomplicated malaria (median age 5 years) were randomly assigned to receive AM or artesunate-amodiaquine [artemisinin combination therapy (ACT)] as first-line treatment. Both treatments were well tolerated. Over 28 days, second-line treatment was not required for 89% (95% CI 84.1-93.2) of patients on AM, versus 95% (95% CI 88.8-98.3) on ACT. Deterioration to severe malaria was 1.9% in both groups in children aged 5 years) and 0% had coma/convulsions. AM, now government-approved in Mali, could be tested as a first-line complement to standard modern drugs in high-transmission areas, in order to reduce the drug pressure for development of resistance to ACT, in the management of malaria. In view of the low rate of severe malaria and good tolerability, AM may also constitute a first-aid treatment when access to other antimalarials is delayed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Preparações de Plantas
/
Argemone
/
Artemisininas
/
Amodiaquina
/
Malária
/
Fitoterapia
/
Antimaláricos
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Adult
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Child
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Child, preschool
/
Female
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Humans
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Infant
/
Male
País/Região como assunto:
Africa
/
Mexico
Idioma:
En
Revista:
Trans R Soc Trop Med Hyg
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Suíça
País de publicação:
Reino Unido