Ethnic polymorphism of DXS52 (St 14) locus linked to coagulation factor VIII gene in Argentina.
Ann Genet
; 33(1): 24-8, 1990.
Article
em En
| MEDLINE
| ID: mdl-1973342
Sixty-five individuals belonging to 16 argentinian families of hemophilia A were studied using the St 14 probe (DXS52 locus). This probe is widely used for carrier detection and prenatal diagnosis, despite the risk of recombination between the factor VIII gene and the DXS52 locus, because of its high informativity. The families are divided in two groups: one group constituted only of metis of Indians according to interview and morphotype and a second group of caucasoids (Spanish essentially and Italian). In this study we have shown some ethnic variations of the TaqI RFLPs in the DXS52 locus. In the allelic system I, (which alleles are numbered from 1 to 8) we have noted an over representation of the larger alleles (2 and 3) and of the allele 8 in both Argentinian groups when compared to the caucasian population already studied in our laboratory. The additional polymorphic TaqI site giving the beta band in the system II (alpha and beta bands) is found more frequently in the Argentinian families than in Caucasians. Some other additional polymorphic sites have been found in generally constant bands giving additional allelic systems, in metis families.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Fator VIII
/
Indígenas Sul-Americanos
/
População Branca
/
Hemofilia A
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Argentina
/
Europa
Idioma:
En
Revista:
Ann Genet
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
França
País de publicação:
Holanda