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Body composition alterations, energy expenditure and fat oxidation in elderly males suffering from prostate cancer, pre and post orchiectomy.
Reis, Cristiana; Liberman, Sami; Pompeo, Antonio Carlos; Srougi, Miguel; Halpern, Alfredo; Filho, Wilson Jacob.
Afiliação
  • Reis C; Department of Geriatric and Gerontology, Department of Endocrinology and Metabolism and Department of Urology, Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brazil. vitalita@uol.com.br
Clinics (Sao Paulo) ; 64(8): 781-4, 2009.
Article em En | MEDLINE | ID: mdl-19690663
INTRODUCTION: Testosterone is needed for normal male development, muscle strength, bone mineralization, hematopoietic function, and sexual and reproductive functions. The main purpose of androgen deprivation therapy in prostate cancer is to reduce tumor progression, but therapy is often accompanied by significant adverse effects. OBJECTIVE: This study aimed to determine the effects of androgen deprivation therapy on body composition and resting metabolic rate in patients with prostate cancer. PATIENTS AND METHODS: A prospective study was performed to evaluate the body composition of 16 elderly males (aged 63-96; median age 71) with prostate cancer scheduled for orchiectomy, one year before and after surgery. Body composition was measured by DEXA, and energy expenditure, fat and carbohydrate oxidation were measured by indirect calorimetry. RESULTS: Body weight (p=0.01), lean mass (p=0.004), and lipid oxidation (p=0.001) decreased significantly. Carbohydrate oxidation (p=0.02), FSH (p=0.0001) and LH (p=0.0001) levels increased significantly. Changes in fat mass (p=0.06) and bone mineral density (p=0.48) were not significant. CONCLUSIONS: After 12 months of androgen deprivation therapy, elderly men with metastatic prostate cancer exhibit a decline in lean body mass and lipid oxidation, together with increased carbohydrate oxidation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Composição Corporal / Orquiectomia / Metabolismo Energético / Metabolismo dos Carboidratos / Metabolismo dos Lipídeos Tipo de estudo: Health_economic_evaluation / Observational_studies Limite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Composição Corporal / Orquiectomia / Metabolismo Energético / Metabolismo dos Carboidratos / Metabolismo dos Lipídeos Tipo de estudo: Health_economic_evaluation / Observational_studies Limite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos