Your browser doesn't support javascript.
loading
Scopadulcic acid B, a new tetracyclic diterpenoid from Scoparia dulcis L. Its structure, H+, K(+)-adenosine triphosphatase inhibitory activity and pharmacokinetic behaviour in rats.
Hayashi, T; Okamura, K; Kakemi, M; Asano, S; Mizutani, M; Takeguchi, N; Kawasaki, M; Tezuka, Y; Kikuchi, T; Morita, N.
Afiliação
  • Hayashi T; Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Chem Pharm Bull (Tokyo) ; 38(10): 2740-5, 1990 Oct.
Article em En | MEDLINE | ID: mdl-1963813
The structure of scopadulcic acid B (2, SDB), a major ingredient of the Paraguayan herb "Typychá kuratu" (Scoparia dulcis L.), was elucidated mainly by comparison of its spectral data with that of scopadulcic acid A (1). SDB inhibited both the K(+)-dependent adenosine triphosphatase (ATPase) activity of a hog gastric proton pump (H+, K(+)-ATPase) with a value of 20-30 microM for IC50 and proton transport into gastric vesicles. Pharmacokinetic studies of SDB in rats indicated that plasma SDB concentrations after i.v. injection of the sodium salt of SDB (SDB-Na) were described reasonably well by a two-compartment open model with Michaelis-Menten elimination kinetics. Plasma concentrations after oral administration of SDB-Na or SDB showed a much slower decline than what was expected following the i. v. study. It was suggested that the sustained plasma level of SDB after oral administration of SDB-Na or SDB was accounted for by relatively slow but efficient gastro-intestinal absorption in rats.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Plantas Medicinais / Adenosina Trifosfatases / Diterpenos Limite: Animals País/Região como assunto: America do sul / Paraguay Idioma: En Revista: Chem Pharm Bull (Tokyo) Ano de publicação: 1990 Tipo de documento: Article País de afiliação: Japão País de publicação: Japão
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Plantas Medicinais / Adenosina Trifosfatases / Diterpenos Limite: Animals País/Região como assunto: America do sul / Paraguay Idioma: En Revista: Chem Pharm Bull (Tokyo) Ano de publicação: 1990 Tipo de documento: Article País de afiliação: Japão País de publicação: Japão