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Associations among the use of highly active antiretroviral therapy, oral candidiasis, oral Candida species and salivary immunoglobulin A in HIV-infected children.
Pomarico, Luciana; Cerqueira, Daniella Ferraz; de Araujo Soares, Rosangela Maria; de Souza, Ivete Pomarico Ribeiro; de Araujo Castro, Gloria Fernanda Barbosa; Socransky, Sigmund; Haffajee, Anne; Teles, Ricardo Palmier.
Afiliação
  • Pomarico L; Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. lupomarico@superig.com.br
Oral Surg Oral Med Oral Pathol Oral Radiol Endod ; 108(2): 203-10, 2009 Aug.
Article em En | MEDLINE | ID: mdl-19615660
OBJECTIVES: The aim was to examine the impact of antiretroviral therapy on the prevalence of oral candidiasis, recovery of oral Candida spp. , and salivary levels of total secretory immunoglobulin A (SIgA) and Candida-specific SIgA in human immunodeficiency virus (HIV)-infected children. STUDY DESIGN: Sixty-six HIV+ and 40 HIV- children were cross-sectionally examined for the presence of oral lesions. Whole stimulated saliva samples were collected for the identification of Candida spp. using culture and measurement of total and specific SIgA using enzyme-linked immunosorbent assay (ELISA). RESULTS: The HIV+ children had a higher prevalence of oral candidiasis (P < .05), higher frequency of detection of Candida spp. (P < .05), and higher levels of total (P < .05) and Candida-specific SIgA (P < .001) than the HIV- children. Among the HIV+ subjects, antiretroviral users had lower viral loads (P < .001) and lower levels of Candida spp. (P < .05) and total SIgA (P < .05) compared with antiretroviral nonusers. CONCLUSIONS: The use of antiretroviral therapy was associated with decreases in the prevalence of oral candidiasis. This diminished exposure to Candida spp. was accompanied by decreases in levels of total and Candida-specific SIgA.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saliva / Candidíase Bucal / Imunoglobulina A Secretora / Infecções por HIV / Terapia Antirretroviral de Alta Atividade Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Assunto da revista: ODONTOLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saliva / Candidíase Bucal / Imunoglobulina A Secretora / Infecções por HIV / Terapia Antirretroviral de Alta Atividade Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Assunto da revista: ODONTOLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos