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Impact of APOE epsilon4 on the cognitive performance of a sample of non-demented Puerto Rican nonagenarians.
Carrión-Baralt, José R; Meléndez-Cabrero, Josefina; Rodríguez-Ubiñas, Heide; Schmeidler, James; Beeri, Michal Schnaider; Angelo, Gary; Sano, Mary; Silverman, Jeremy M.
Afiliação
  • Carrión-Baralt JR; Mount Sinai School of Medicine, Department of Psychiatry, New York, NY, USA. jose.carrion-baralt@mssm.edu
J Alzheimers Dis ; 18(3): 533-40, 2009.
Article em En | MEDLINE | ID: mdl-19584451
APOE epsilon4 is a major risk factor for Alzheimer's disease. It has also been associated with cognitive impairment and cognitive decline in young-olds, but the impact of the epsilon4 allele on cognitive function in very late life is still unclear. The object of this study was to evaluate the association of the epsilon4 allele of APOE with the cognitive performance of a sample of non-demented oldest-olds. Eighty-seven Spanish-speaking Puerto Rican non-demented nonagenarians were administered a complete neuropsychological assessment and provided a blood sample used for APOE genotyping. A factor analysis generated two factors: 1) verbal memory; and 2) visuo-spatial, naming and attention tasks, accounting for 43.6% of the overall variance in the 13 original neuropsychological variables. The multivariate analysis reflected, after controlling for gender, education, and age, the APOE epsilon4 carriers performed better in overall cognition (both factors analyzed together) than non-carriers (T;{2} = 0.082, F(2,80) = 3.289, p = 0.042). Neither gender nor the gender by APOE epsilon4 status interaction was associated with differences in cognition. In conclusion, the results of this study suggest that, among these Puerto Rican non-demented nonagenarians, being an APOE epsilon4 allele carrier is associated with better cognition.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Cognitivos / Apolipoproteína E4 Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Aged80 / Female / Humans / Male País/Região como assunto: Caribe / Puerto rico Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Cognitivos / Apolipoproteína E4 Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Aged80 / Female / Humans / Male País/Região como assunto: Caribe / Puerto rico Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda