Stem cells: therapeutic potential in dentistry.
J Contemp Dent Pract
; 10(4): 90-6, 2009 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-19575059
AIM: The aim of this paper is to present a review and discussion of the current status of stem cell research with regard to tooth generation. BACKGROUND: Stem cells have been isolated from the pulp tissue of both deciduous and permanent teeth as well as from the periodontal ligament. Dental pulp stem cells demonstrate the capacity to form a dentin pulp-like complex in immunocompromised mice. A tooth-like structure was successfully formed, using a heterogeneous mixture of dental enamel epithelium, pulp mesenchymal cells, and scaffolds. CONCLUSION: The scientific community understands the need for more investigations to completely understand the conditions that would best favor the creation of a tooth substitute. Recent gains in the understanding of the molecular regulation of tooth morphogenesis, stem cell biology, and biotechnology offers the opportunity to realize this goal. CLINICAL SIGNIFICANCE: These findings, combined with the recent progress in stem cell research and tissue engineering, might allow the development of alternatives for current materials and therapies used to treat tooth tissue loss (e.g., enamel, dentin, pulp), reconstruct dentoalveolar and craniofacial bone defects, and eventually replace an entire tooth.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Dente
/
Células-Tronco Adultas
/
Células-Tronco Mesenquimais
/
Odontogênese
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Contemp Dent Pract
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Índia