The role of free radicals in sepsis development.
Front Biosci (Elite Ed)
; 1(1): 277-87, 2009 06 01.
Article
em En
| MEDLINE
| ID: mdl-19482645
Sepsis is a complex inflammatory syndrome with diverse etiology and wide spectrum of severity. Several researchers have linked reactive oxygen species (ROS) and reactive nitrogen species (RNS) with the onset, progression and outcome of sepsis, both in pre-clinical and in clinical studies. ROS/RNS are important signaling molecules but its overproduction must be avoided by organism, otherwise oxidative stress takes place. Even so, the use of antioxidant as treatment in sepsis constitutes a challenge, with both null and encouraging results. In this review, it will be summarized the role of free radicals in the onset, progression and outcome of sepsis, as well as its participation in organ failure and cardiovascular collapse. Experimental treatments that may interfere in oxidative stress in sepsis will also be contemplated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sepse
/
Estresse Oxidativo
/
Espécies Reativas de Nitrogênio
/
Radicais Livres
/
Mitocôndrias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Front Biosci (Elite Ed)
Assunto da revista:
BIOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Singapura