Your browser doesn't support javascript.
loading
Chromosome aberrations in workers exposed to organic solvents: Influence of polymorphisms in xenobiotic-metabolism and DNA repair genes.
Hoyos-Giraldo, Luz Stella; Carvajal, Silvio; Cajas-Salazar, Nohelia; Ruíz, Martín; Sánchez-Gómez, Adalberto.
Afiliação
  • Hoyos-Giraldo LS; Department of Biology, Research Group Genetic Toxicology and Cytogenetics, Faculty of Natural Sciences and Education, Universidad del Cauca, Popayán, Cauca, Colombia. lshoyos@unicauca.edu.co
Mutat Res ; 666(1-2): 8-15, 2009 Jun 18.
Article em En | MEDLINE | ID: mdl-19481674
Organic solvents are widely used as diluents or thinners for oil-paints, gasoline and other organic mixtures. We evaluated chromosome aberrations (CAs) in lymphocytes of 200 workers exposed to organic solvents and 200 referents and the influence of polymorphisms in xenobiotic-metabolism (CYP2E1, GSTM1 and GSTT1) and in DNA repair genes (XRCC1(194) Arg/Trp, XRCC1(280) Arg/His, XRCC1(399) Arg/Gln and XRCC3(241) Thr/Met). Polymorphisms were determined by PCR-RFLP. Poisson regression analysis indicates a significant CA frequency increase in exposed workers, representing a higher risk in relation to the matched referent (RR 2.15, 95% CI 1.21-1.53, p<0.001). The CA frequency in exposed workers was influenced by the polymorphic genotypes: GSTM1 null (RR 1.33, 95% CI 1.31-1.69, p<0.001), XRCC1(194) Arg/Trp, Trp/Trp (RR 1.23, 95% CI 1.08-1.40, p<0.001) and by the wild genotypes CYP2E1 C1/C1 (RR 1.20, 95% CI 1.05-1.37, p<0.001), GSTT1 positive (RR 1.49, 95% CI 1.31-1.69, p<0.001), XRCC1(280) Arg/Arg (RR 1.44, 95% CI 1.26-1.64, p<0.001) and XRCC1(241) Thr/Thr (RR 1.54, 95% CI 1.34-1.76, p=0.001). We contribute to the follow-up predictive value of individual susceptibility biomarkers and their CA frequency influence during occupational organic solvent exposure. We provide tools for surveillance and prevention strategies to reduce potential health risks in countries with a large population of car painters not using protection devices and limited organic solvents use control.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Orgânicos / Polimorfismo Genético / Solventes / Xenobióticos / Exposição Ocupacional / Aberrações Cromossômicas / Enzimas Reparadoras do DNA / Reparo do DNA Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Mutat Res Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Orgânicos / Polimorfismo Genético / Solventes / Xenobióticos / Exposição Ocupacional / Aberrações Cromossômicas / Enzimas Reparadoras do DNA / Reparo do DNA Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Mutat Res Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Holanda