Membrane-incorporated immunoglobulin receptors increase the antigen-presenting ability of B cells.

Gontijo, C M; Möller, G

Gontijo, C M; Möller, G.

Afiliação

Gontijo CM; Department of Biochemistry and Immunology, Federal University of Minas Gerais, Brazil.

Scand J Immunol ; 34(5): 577-84, 1991 Nov.

Article em En | MEDLINE | ID: mdl-1947793

RESUMO

Monoclonal antibodies specific for ovalbumin were conjugated to palmitate and inserted into the membrane of normal spleen B cells. Their presence in the membrane, as well as their ability to bind ovalbumin, was established by immunofluorescence. The so called anti-ovalbumin-'decorated' B cells were tested for their ability to act as antigen-presenting cells for ovalbumin-specific I-Ad-restricted T-cell hybridomas. It was found that the antibody-decorated B cells presented antigen more efficiently than non-decorated B cells.

Assuntos

Células Apresentadoras de Antígenos/imunologia; Linfócitos B/imunologia; Receptores de Antígenos de Linfócitos B/fisiologia; Receptores Imunológicos/fisiologia; Animais; Feminino; Hibridomas/imunologia; Imunoglobulina M/imunologia; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Ovalbumina/imunologia

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Receptores de Antígenos de Linfócitos B / Receptores Imunológicos / Células Apresentadoras de Antígenos Limite: Animals Idioma: En Revista: Scand J Immunol Ano de publicação: 1991 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

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