Hypothalamic regulation of food intake and clinical therapeutic applications.
Arq Bras Endocrinol Metabol
; 53(2): 120-8, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-19466203
Current estimates suggest that over 1 billion people are overweight and over 300 million people are obese. Weight gain is due to an imbalance between energy expenditure and dietary intake. This review discusses the hypothalamic control of appetite and highlights key developments in research that have furthered our understanding of the complex pathways involved. Nuclei within the hypothalamus integrate peripheral signals such as adiposity and caloric intake to regulate important pathways within the central nervous system controlling food intake and energy expenditure. Firmly established pathways involve the orexigenic NPY/AgRP and the anorexigenic POMC/CART neurons in the arcuate nucleus (ARC) of the hypothalamus. These project from the ARC to other important hypothalamic nuclei, including the paraventricular, dorsomedial, ventromedial and lateral hypothalamic nuclei. In addition there are many projections to and from the brainstem, cortical areas and reward pathways, which modulate food intake.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação do Apetite
/
Comportamento Alimentar
/
Hipotálamo
/
Obesidade
Limite:
Humans
Idioma:
En
Revista:
Arq Bras Endocrinol Metabol
Ano de publicação:
2009
Tipo de documento:
Article
País de publicação:
Brasil