Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii.
J Nat Prod
; 72(5): 805-12, 2009 May 22.
Article
em En
| MEDLINE
| ID: mdl-19405508
Cytotoxicity-guided fractionation of an organic solvent extract of the plant Crossosoma bigelovii led to the discovery of a new strophanthidin glycoside (1) and two new 2-methylchromone glycosides (2 and 3). Also isolated were the known chromones eugenin and noreugenin, the indole alkaloid ajmalicine, the dibenzylbutane lignan secoisolariciresinol, the dibenzylbutyrolactone lignan matairesinol, and the furanone 5-tetradec-5-enyldihydrofuran-2-one. Further investigation into the biological properties of strophanthidin glycosides revealed a connection between inhibition of HIF-1 activation and the glycosylation of the genin. This work is the first published study of the bioactive phytochemicals of the family Crossosomataceae.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Cardenolídeos
/
Cromonas
/
Magnoliopsida
/
Subunidade alfa do Fator 1 Induzível por Hipóxia
/
Glicosídeos
/
Antineoplásicos Fitogênicos
Limite:
Female
/
Humans
País/Região como assunto:
Mexico
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Estados Unidos