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Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: an experimental study that supports a potential new application of BNCT.
Monti Hughes, A; Heber, E M; Pozzi, E; Nigg, D W; Calzetta, O; Blaumann, H; Longhino, J; Nievas, S I; Aromando, R F; Itoiz, M E; Trivillin, V A; Schwint, A E.
Afiliação
  • Monti Hughes A; Department of Radiobiology, National Atomic Energy Commission (CNEA), Buenos Aires, Argentina.
Appl Radiat Isot ; 67(7-8 Suppl): S313-7, 2009 Jul.
Article em En | MEDLINE | ID: mdl-19376711
We previously demonstrated the efficacy of boron neutron capture therapy (BNCT) mediated by boronophenylalanine (BPA), GB-10 (Na(2)(10)B(10)H(10)) and (GB-10+BPA) to control tumors, with no normal tissue radiotoxicity, in the hamster cheek pouch oral cancer model. Herein we developed a novel experimental model of field-cancerization and precancerous lesions (globally termed herein precancerous tissue) in the hamster cheek pouch to explore the long-term potential inhibitory effect of the same BNCT protocols on the development of second primary tumors from precancerous tissue. Clinically, second primary tumor recurrences occur in field-cancerized tissue, causing therapeutic failure. We performed boron biodistribution studies followed by in vivo BNCT studies, with 8 months follow-up. All 3 BNCT protocols induced a statistically significant reduction in tumor development from precancerous tissue, reaching a maximum inhibition of 77-100%. The inhibitory effect of BPA-BNCT and (GB-10+BPA)-BNCT persisted at 51% at the end of follow-up (8 months), whereas for GB-10-BNCT it faded after 2 months. Likewise, beam-only elicited a significant but transient reduction in tumor development. No normal tissue radiotoxicity was observed. At 8 months post-treatment with BPA-BNCT or (GB-10+BPA)-BNCT, the precancerous pouches that did not develop tumors had regained the macroscopic and histological appearance of normal (non-cancerized) pouches. A potential new clinical application of BNCT would lie in its capacity to inhibit local regional recurrences.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesões Pré-Cancerosas / Terapia por Captura de Nêutron de Boro Tipo de estudo: Evaluation_studies / Guideline Limite: Animals Idioma: En Revista: Appl Radiat Isot Assunto da revista: MEDICINA NUCLEAR / SAUDE AMBIENTAL Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesões Pré-Cancerosas / Terapia por Captura de Nêutron de Boro Tipo de estudo: Evaluation_studies / Guideline Limite: Animals Idioma: En Revista: Appl Radiat Isot Assunto da revista: MEDICINA NUCLEAR / SAUDE AMBIENTAL Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido