Blood-brain barrier ultrastructural alterations in human congenital hydrocephalus and Arnold-Chiari malformation.
Folia Neuropathol
; 47(1): 11-9, 2009.
Article
em En
| MEDLINE
| ID: mdl-19353430
Cortical biopsies of 13 patients with clinical diagnosis of congenital hydrocephalus, Arnold-Chiari malformation and hydrocephalus, and postmeningitis hydrocephalus were examined by transmission electron microscopy to study the damage of endothelial cells, basement membrane, astrocytic end-feet layer, and perivascular space. Capillaries from the parietal and frontal cortex showed increased vesicular and vacuolar transport, intact endothelial junctions, thin and immature basement membrane, swollen perivascular astrocytic end-feet layer, and enlarged perivascular space. In areas of severe oedema, open endothelial junctions, swollen basement membrane, absent perivascular astrocytic end-feet layer, enlarged perivascular space, and disrupted perivascular neuropil were observed. The electron microscopic findings demonstrated breakdown of the blood-brain barrier in all cases examined.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Malformação de Arnold-Chiari
/
Barreira Hematoencefálica
/
Hidrocefalia
Limite:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
Idioma:
En
Revista:
Folia Neuropathol
Assunto da revista:
NEUROLOGIA
/
PATOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Venezuela
País de publicação:
Polônia