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Attitudes and knowledge about genetic testing before and after finding the disease-causing mutation among individuals at high risk for familial, early-onset Alzheimer's disease.
Marcheco-Teruel, Beatriz; Fuentes-Smith, Evelyn.
Afiliação
  • Marcheco-Teruel B; National Centre of Medical Genetics, Havana, Cuba. beatriz@infomed.sld.cu
Genet Test Mol Biomarkers ; 13(1): 121-5, 2009 Feb.
Article em En | MEDLINE | ID: mdl-19309285
This study was designed to investigate the influence of finding a disease-causing mutation for an early-onset form of Alzheimer's disease, with the intention of taking a presymptomatic genetic test. First-degree relatives of patients with Alzheimer's disease from a large Cuban family with a newly described mutation in presenilin 1 gene were interviewed before and after molecular studies. Significant differences were observed regarding the knowledge of the disease (p=0.0004), interest in presymptomatic testing (p=0.000), and possible reproductive behavior (p=0.0087) in the same individuals in two different periods, 1997 and 2007. Our results show that there is a marked difference in the attitudes concerning genetic testing when individuals gain more knowledge about the disease and when there is more certainty about the test.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes Genéticos / Conhecimentos, Atitudes e Prática em Saúde / Doença de Alzheimer Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged / Pregnancy País/Região como assunto: Caribe / Cuba Idioma: En Revista: Genet Test Mol Biomarkers Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Cuba País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes Genéticos / Conhecimentos, Atitudes e Prática em Saúde / Doença de Alzheimer Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged / Pregnancy País/Região como assunto: Caribe / Cuba Idioma: En Revista: Genet Test Mol Biomarkers Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Cuba País de publicação: Estados Unidos