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Serotonin and sensitivity to trauma-related exposure in selective serotonin reuptake inhibitors-recovered posttraumatic stress disorder.
Corchs, Felipe; Nutt, David J; Hood, Sean; Bernik, Marcio.
Afiliação
  • Corchs F; Anxiety Disorders Unit, Department and Institute of Psychiatry, University of São Paulo, Brazil. felipe.corchs@hotmail.com
Biol Psychiatry ; 66(1): 17-24, 2009 Jul 01.
Article em En | MEDLINE | ID: mdl-19268914
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are first-line treatments for posttraumatic stress disorder (PTSD). Serotonergic (5HT) attenuation of stress sensitivity is postulated from SSRIs' effects in other anxiety disorders, and we studied this in PTSD. METHODS: Ten patients with PTSD fully recovered on SSRIs (Clinical Global Impression Scale-I 1 and 2) were enrolled in the study. Patients were tested on two occasions 1 week apart; in each session, they received a drink containing large neutral amino acids (LNAAs) either with (sham tryptophan depletion [STD], control) or without (acute tryptophan depletion [ATD]) tryptophan. At 5.5 hours after the drink, subjects were exposed to a trauma-related exposure challenge. Self-reports of PTSD (visual analogue scales [VAS] and the Davidson Trauma Scale [DTS]), anxiety (Spielberger State Inventory [STAI] Form Y-1), and mood (Profile of Mood States [POMS]) were obtained. Heart rate (HR), systolic (SBP) and diastolic (DBP) blood pressure were also measured. RESULTS: The trauma-related exposure challenge induced anxiety on both days, with more marked responses on the ATD day according to VAS, DTS, POMS, and DBP (p < .05). A trend of significance (.1 > p > .05) was observed for STAI Form Y-1, HR, and SBP. CONCLUSIONS: These data demonstrate that ATD accentuates responses to trauma-related stimuli in SSRI-recovered PTSD. They also suggest that SSRI-induced increases in serotonin function restrain PTSD symptoms, especially under provocation, supporting a role for serotonin in mediating stress resilience.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos de Ansiedade / Transtornos de Estresse Pós-Traumáticos / Serotonina / Inibidores Seletivos de Recaptação de Serotonina Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Biol Psychiatry Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos de Ansiedade / Transtornos de Estresse Pós-Traumáticos / Serotonina / Inibidores Seletivos de Recaptação de Serotonina Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Biol Psychiatry Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos