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Saline extract of Taenia saginata metacestodes as an alternative antigen for the immunodiagnosis of neurocysticercosis in human cerebrospinal fluid.
Oliveira, Heliana B; Machado, Gleyce A; Gonçalves-Pires, Maria do Rosário F; Moura, Leandro P; Costa-Cruz, Julia M.
Afiliação
  • Oliveira HB; Departamento de Imunologia, Microbiologia e Parasitologia, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Minas Gerais, Brazil.
Parasitol Res ; 105(1): 169-74, 2009 Jul.
Article em En | MEDLINE | ID: mdl-19247689
The aim of the present research was to test the application of Taenia saginata metacestodes as an alternative antigen for use in enzyme-linked immunosorbent assay (ELISA) and Western Blotting (WB) tests compared with the use of metacestodes antigen of Taenia solium in cerebrospinal fluid (CSF) samples. The samples were obtained from 35 patients with definitive neurocysticercosis (NCC)-group 1-and 44 patients with other neurological disorders (control)-group 2. The sensitivity and specificity of ELISA, using antigen obtained from T. solium, applied to the patients of group 1 yielded results of 100%. When the tests were conducted using T. saginata metacestodes, results were 100% and 93.2%, respectively. The 47-52-, 64-68-, and 70-kDa antigens showed high frequencies in CSF samples from patients with NCC when WB was conducted with both antigens. The results indicate that T. saginata metacestodes can be used as an alternative antigen for the diagnosis of human NCC in CSF samples.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Anti-Helmínticos / Neurocisticercose / Taenia saginata / Taenia solium / Antígenos de Helmintos Tipo de estudo: Diagnostic_studies / Evaluation_studies Limite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Parasitol Res Assunto da revista: PARASITOLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Anti-Helmínticos / Neurocisticercose / Taenia saginata / Taenia solium / Antígenos de Helmintos Tipo de estudo: Diagnostic_studies / Evaluation_studies Limite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Parasitol Res Assunto da revista: PARASITOLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha