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Evaluation of toxicity of surgery and/or chemoirradiation treatment of uterine cervix cancer.
Tormo Ferrero, V; Andreu Martínez, F J; Cardenal Maciá, R.
Afiliação
  • Tormo Ferrero V; Servicio de Oncología Radioterápica, Hospital Universitari Sant Joan d'Alacant, Sant Joan d'Alacant, Alicante, Spain. vitorfe@coma.es
Clin Transl Oncol ; 11(2): 109-13, 2009 Feb.
Article em En | MEDLINE | ID: mdl-19211377
OBJECTIVE: To evaluate acute and chronic toxicity of chemoirradiation treatment (neoadjuvant, adjuvant and radical treatment) in patients diagnosed with cervix cancer. METHODS: From December 1999 to August 2007, 53 patients diagnosed with adenocarcinoma or squamous cell carcinoma of the uterine cervix received neoadjuvant, adjuvant or radical chemoirradiation. RESULTS: Acute gastrointestinal toxicity of grade 3 or more in 9 patients (17%) and haematological toxicity of grade 3 or more in 9 patients (17%). Chronic toxicity of grade 3 or more was shown in only 2 patients (4%). The most frequent toxicities were gastrointestinal toxicity and haematological toxicity. The most frequent chronic toxicities were gastrointestinal toxicity and vaginal toxicity. CONCLUSIONS: We report that the combined neoadjuvant, adjuvant or radical chemoirradiation treatment with weekly cisplatin chemotherapy (40 mg/m(2)/week) in patients diagnosed with cervix cancer is a well tolerated treatment and chronic and acute toxicity is low-grade. This treatment scheme has easy compliance.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias do Colo do Útero Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias do Colo do Útero Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália