Antiulcerogenic action of ethanolic extract of the resin from Virola surinamensis Warb. (Myristicaceae).
J Ethnopharmacol
; 122(2): 406-9, 2009 Mar 18.
Article
em En
| MEDLINE
| ID: mdl-19162155
ETHNOPHARMACOLOGICAL RELEVANCE: Virola surinamensis (Myristicaceae), popularly known as "mucuíba", "ucuuba" or "ucuúba do igapó" is a large tree that grows abundantly in "Várzea" forest and on river banks in the Brazilian states of Amazonas and Tocantins. The resin obtained by cuts on the stem bark is a reputed folk remedy in its natural form for the treatment of ulcer, gastritis, inflammation and cancer. AIM OF THE STUDY: The present work evaluated the pharmacological activity of the resin obtained from bark of V. surinamensis as antiulcerogenic in experimental in vivo model in order to observe whether its traditional use is justified. MATERIALS AND METHODS: The preventive action of ethanolic extract of V. surinamensis was evaluated in experimental in vivo models in rodents that simulated this disease in human gastric mucosa. RESULTS: Oral administration of acidified ethanol solution produced severe hemorrhagic lesions in glandular mucosa with ulcerative lesion of 50+/-11.5mm. In animals pretreated with V. surinamensis (500 mg/kg, p.o.) a significant inhibition of mucosal injury of 2.40+/-0.56 mm (95% inhibition) was detected. The V. surinamensis, at the same dose, also reduced significantly (p<0.05) the formation of gastric lesions induced by indomethacin (39%), stress (45%) and by pylorus ligature in mice (31%) when compared to animals treated with vehicle. The extract from V. surinamensis exerts gastroprotective action only when this extract contacts gastric mucosa (oral route) with increased pH values and reduced H+ concentration of gastric contents. The ethanolic extract of V. surinamensis resin was analyzed by TLC and spectrometric methods (NMR and ES-MS) and the main constituent of this extract was epicatechin. CONCLUSIONS: We suggest that the epicatechin present in V. surinamensis resin may be among active principles responsible for the antiulcer activity shown by the tested resin but their used suggest carefulness because toxicological symptoms mentioned by population.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Úlcera Gástrica
/
Extratos Vegetais
/
Catequina
/
Myristicaceae
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Mucosa Gástrica
/
Fitoterapia
/
Antiulcerosos
Limite:
Animals
País/Região como assunto:
America do sul
/
Caribe ingles
/
Suriname
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Irlanda