Polymorphisms of p53, GSTM1 and GSTT1, and HPV in uterine cervix adenocarcinoma.

de Carvalho, C R Nogueira; da Silva, I D C Guerreiro; Pereira, J S; de Souza, N C Nogueira; Focchi, G Rubino de Azevedo; Ribalta, J C L

de Carvalho, C R Nogueira; da Silva, I D C Guerreiro; Pereira, J S; de Souza, N C Nogueira; Focchi, G Rubino de Azevedo; Ribalta, J C L.

Afiliação

de Carvalho CR; Department of Gynecology, Universidade Federal de São Paulo/Escola Paulista de Medicina, Brazil. carmenrcarvalho@uol.com.br

Eur J Gynaecol Oncol ; 29(6): 590-3, 2008.

Article em En | MEDLINE | ID: mdl-19115684

RESUMO

OBJECTIVE: To analyze the participation of glutathione-S-transferase (GST) M1 and T1 polymorphisms associated or not with protein p53 polymorphism at codon 72 and in the presence of HPV in the carcinogenesis of uterine cervix adenocarcinoma. METHODS: Forty-three samples of uterine cervix adenocarcinoma were studied and 86 samples of endocervical cells of women without tumors formed the control group. The presence of HPV was determined in order to genotype the isoforms of p53 at codon 72, GSTM1, GSTM1*0, GSTT1 and GSTT1*0 which were evaluated by the PCR method. RESULTS: HPV was present in 97.67% of the adenocarcinoma cases and in 31.40% of the control group. Statistical analysis showed differences (p = 0.001) and an OR of 113.3 (CI 95%: 13.67-947.14). GSTT1 and GSTT1*0 analysis showed a significant difference between the groups (p = 0.001) with an OR of 4.58 (CI 95%: 2.041-10.28) (p < 0.001) for the presence of GSTT1*0. When it was associated with HPV OR was 6.6 (CI 95%: 0.04-0.50). Analyses of p53 and GSTM1 and GSTM1*0 either alone or associated with HPV were not significant. CONCLUSION: The presence of GSTT1*0 increased the risk for uterine cervix adenocarcinoma development while the allele GSTT1 had a protective action. The other isoforms did not appear to participate in the carcinogenesis of uterine cervix adenocarcinoma.

Assuntos

Adenocarcinoma/genética; Alphapapillomavirus/isolamento & purificação; Glutationa Transferase/genética; Polimorfismo de Nucleotídeo Único/genética; Neoplasias do Colo do Útero/genética; Adulto; Idoso; Idoso de 80 Anos ou mais; Estudos de Casos e Controles; Estudos de Coortes; Feminino; Genes p53/genética; Humanos; Pessoa de Meia-Idade; Razão de Chances; Adulto Jovem

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenocarcinoma / Neoplasias do Colo do Útero / Polimorfismo de Nucleotídeo Único / Alphapapillomavirus / Glutationa Transferase Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Eur J Gynaecol Oncol Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Singapura

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