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[Comparison of metoprolol vs clonazepam as a first treatment choice among patients with neurocardiogenic syncope]. / Comparación de metoprolol versus clonazepam como tratamiento de primera intención en pacientes con síncope neurocardiogénico.
Márquez, Manlio F; Urias-Medina, Karla; Gómez-Flores, Jorge; Sobrino, Ayax; Sotomayor-González, Arturo; González-Hermosillo, Antonio; Cárdenas, Manuel.
Afiliação
  • Márquez MF; Departamento de Electrocardiología, Instituto Nacional de Cardiología Ignacio Chávez, SSA, Tlalpan, México DF, México. manliomarquez@yahoo.com
Gac Med Mex ; 144(6): 503-7, 2008.
Article em Es | MEDLINE | ID: mdl-19112723
OBJECTIVE: We compared the effects of a metoprolol and clonazepam in patients with neurocardiogenic syncope. METHODS: We compared the effects of a metoprolol and clonazepam in a prospective, randomised trial in 54 patients. Patients were randomly assigned to metoprolol (starting dose 50 mg bid) or clonazepam (starting dose 0.5 mg qd). We assessed a primary combined endpoint of syncope and pre-syncope on a follow-up of 12 months. RESULTS: The primary combined endpoint of syncope and presyncope occurred in the metoprolol group in 3, 4, and 10% of patients at 3, 6, and 12 months respectively. In the clonazepam group it was no recurrence in the first 6 months, and 5% recurrence at 12 months follow-up (nonsignificant differences between groups). Clinical symptoms commonly associated with neurally mediated syncope were decreased similarly in both treatment groups, in the metoprolol group from 5.2+/-2.5 to 1.9+/-2.1 (p < 0.001) and in the clonazepam group from 5.5+/-2.5 to 1.5+/-2.2 (p<0.001). CONCLUSIONS: Pharmacological treatment of neurocardiogenic syncope with metoprolol or clonazepam resulted in similar prevention of syncope and presyncope. Both treatments decreased clinical symptoms but complete symptomatic resolution was rarely observed.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Clonazepam / Antagonistas Adrenérgicos beta / Síncope Vasovagal / Metoprolol Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Idioma: Es Revista: Gac Med Mex Ano de publicação: 2008 Tipo de documento: Article País de publicação: México
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Clonazepam / Antagonistas Adrenérgicos beta / Síncope Vasovagal / Metoprolol Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Idioma: Es Revista: Gac Med Mex Ano de publicação: 2008 Tipo de documento: Article País de publicação: México