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Renal transplantation in patients with classical haemolytic-uraemic syndrome.
Bassani, C E; Ferraris, J; Gianantonio, C A; Ruiz, S; Ramirez, J.
Afiliação
  • Bassani CE; Department of Paediatrics, Hospital Italiano de Buenos Aires, Argentina.
Pediatr Nephrol ; 5(5): 607-11, 1991 Sep.
Article em En | MEDLINE | ID: mdl-1911148
Eighteen records from children with renal transplants (RT) and classical haemolytic-uraemic syndrome (HUS) were reviewed. The mean oliguric period was 17.9 +/- 7.5 days; the interval between acute phase and end-stage renal disease (ESRD) was 9.3 +/- 5.2 years. HUS was the most frequent cause of renal transplantation (23.4%). There were no significant differences between patients with HUS and controls (children with RT but without HUS), regarding renal function, frequency of rejections, renal survival (HUS 65%, controls 57%) or patient survival (94.4% and 96.6%, respectively) after 9 years. None had clinical or histopathological evidence of HUS recurrence in the allograft. Of all children with living-related donors (LRD), renal survival after 3 years was longer for those who received cyclosporin A (CSA) (HUS and controls 86%) than for those who did not receive it (HUS 50%, controls 53%). Classical HUS is a frequent cause of ESRD in Argentina. The duration of the acute oliguric period is a good predictor of the likelihood of progression to chronicity. In the classical form of HUS there is no recurrence in the allograft. CSA and LRD can be used without risk in renal transplantation of children with classical HUS.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Rim / Síndrome Hemolítico-Urêmica Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Pediatr Nephrol Assunto da revista: NEFROLOGIA / PEDIATRIA Ano de publicação: 1991 Tipo de documento: Article País de afiliação: Argentina País de publicação: Alemanha
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Rim / Síndrome Hemolítico-Urêmica Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Pediatr Nephrol Assunto da revista: NEFROLOGIA / PEDIATRIA Ano de publicação: 1991 Tipo de documento: Article País de afiliação: Argentina País de publicação: Alemanha