Alfentanil pharmacokinetics in piglets with increased intra-abdominal pressure.
Dev Pharmacol Ther
; 16(1): 53-8, 1991.
Article
em En
| MEDLINE
| ID: mdl-1879253
Increased intra-abdominal pressure (IAP) occurs in pediatric patients with end-stage liver disease and ascites, as well as in children following surgery for diaphragmatic hernia, omphalocele, gastroschisis and orthotopic liver transplantation. Although the hemodynamic response to increased IAP is well described, little information is available regarding the effects of IAP on drug distribution and elimination. We studied the effects of increased IAP (20 mm Hg) on the pharmacokinetics of alfentanil in piglets and compared these findings with those in control animals. Increased IAP appears to have no significant effect on the volume of distribution (0.46 +/- 0.06 vs. 0.61 +/- 0.23 liter/kg), mean residence time (68.8 +/- 27.8 vs. 62.3 +/- 27.8 min) and elimination half-life (47.7 +/- 19.0 vs. 43.2 +/- 19.3 min).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alfentanil
/
Abdome
Limite:
Animals
Idioma:
En
Revista:
Dev Pharmacol Ther
Ano de publicação:
1991
Tipo de documento:
Article
País de publicação:
Suíça