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Leptin in nonalcoholic fatty liver disease.
Canbakan, Billur; Tahan, Veysel; Balci, Huriye; Hatemi, Ibrahim; Erer, Burak; Ozbay, Gulsen; Sut, Necdet; Hacibekiroglu, Munire; Imeryuz, Nese; Senturk, Hakan.
Afiliação
  • Canbakan B; Istanbul Science University, Avrupa Florence Nightingale Hospital Research Center, Department of Gastroenterology, Istanbul, Turkey.
Ann Hepatol ; 7(3): 249-54, 2008.
Article em En | MEDLINE | ID: mdl-18753993
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a prevalent condition associated with obesity and insulin resistance (IR). Leptin plays a key role in the control of energy balance, and insulin sensitivity. In this study, we aimed to examine whether serum leptin levels correlate with insulin resistance, oxidative stress parameters and the severity of histological changes in NAFLD. METHODS: Fifty-two patients (M/F: 28/24) with no alcohol intake and biopsy-proven diagnosis of NAFLD were studied. Serum leptin levels were measured by radioimmunoassay. HOMA (homeostasis model assessment) IR index was calculated. Comparisons between the patients with NAFLD and non-alcoholic steatohepatitis (NASH) were performed using the Student's t test. Multivariate regression analysis and the area under the receiver operating characteristic (ROC) curve were used to identify the independent predictors for NASH. RESULTS: We found no association between serum leptin, fasting insulin levels, and oxidative stress parameters. ROC curve and multiple regression analysis revealed no association between the severity of histological changes and serum leptin levels. During six months followed-up period only NASH group with elevated leptin levels had significant reductions of ALT and AST values (p = 0.03, and 0.005, respectively). CONCLUSION: Our findings show a preventive effect of leptin against progressive liver injury in NAFLD.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Estresse Oxidativo / Leptina / Fígado Gorduroso / Fígado Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Turquia País de publicação: México
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Estresse Oxidativo / Leptina / Fígado Gorduroso / Fígado Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Turquia País de publicação: México